Genetic Cholestasis: Lessons from the Molecular Physiology of Bile Formation
نویسندگان
چکیده
منابع مشابه
Molecular regulation of sinusoidal liver bile acid transporters during cholestasis.
Impairment of the hepatic transport of bile acids and other organic anions will result in the clinically important syndrome of cholestasis. Cloning of a number of specific hepatic organic anion transporters has enabled studies of their molecular regulation during cholestasis. The best characterized transport system is a 50-51 kDa sodium-dependent taurocholate cotransporting polypeptide (ntcp), ...
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Active canalicular secretion of bile salts and non-bile salt organic anions represents the major driving force of hepatic bile formation. The most important carriers involved have now been cloned on both the basolateral and canalicular sides of hepatocytes. Elucidation of their structure, transport properties, and regulation is an important step forward in the ultimate understanding of the mole...
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ژورنال
عنوان ژورنال: Canadian Journal of Gastroenterology
سال: 2000
ISSN: 0835-7900
DOI: 10.1155/2000/514172